SnapShot: Homologous Recombination in DNA Double-Strand Break Repair
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چکیده
منابع مشابه
SnapShot: Homologous Recombination in DNA Double-Strand Break Repair
Homologous recombination (HR) provides an important mechanism to repair both accidental and programmed DNA double-strand breaks (DSBs) during mitosis and meiosis. Defects in HR are associated with mutagenesis and predispose to cancer, highlighting the importance of this pathway for preserving genome integrity (Moynahan and Jasin, 2010). HR is active in the S and G2 phases of the cell cycle wher...
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ownloade C regulates a myriad of genes controlling cell proliferation, metabolism, differentiation, and apoptosis. lso controls the expression of DNA double-strand break (DSB) repair genes and therefore may be a ial target for anticancer therapy to sensitize cancer cells to DNA damage or prevent genetic instability. report, we studied whether MYC binds to DSB repair gene promoters and modulates...
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ژورنال
عنوان ژورنال: Cell
سال: 2010
ISSN: 0092-8674
DOI: 10.1016/j.cell.2010.08.006